December 7, 2022
We are pleased to announce that Critical Reviews™ in Immunology has peer-reviewed and published our 3rd paper where we describe how the SPIRAL model, a unique antigen-specific interpretive framework, provides a mechanism for the control of pathological T helper responses by Foxp3+ regulatory T cells (Tregs). To read click SPIRAL 3.
August 12, 2021
We are pleased to share that part 3 of the SPIRAL model has now been published as a preprint. In this paper we explore the connection between pathological T helper (Th) responses and pre-existing cross-reactive memory T cells. To read click SPIRAL 3.
July 22, 2020
The Scandinavian Journal of Immunology has peer-reviewed and published our 2nd paper on the
SPIRAL model. In this paper we explore the mechanism of Foxp3+ regulatory T cell (Treg) development in the thymus and how this process could be linked via cross-reactivity to subsequent immunopathologies. To read the abstract click SPIRAL 2.
July 11, 2019
We are pleased to share that part 2 of the SPIRAL model has now been published as a preprint.In this paper we explore the mechanism of Foxp3+ regulatory T cell (Treg) development in the thymus and how this process could be linked via cross-reactivity to subsequent immunopathologies. To read click SPIRAL 2.
August 21, 2018
We are pleased to announce that the Scandinavian Journal of Immunology has peer-reviewed and published our 1st paper where we describe how the SPIRAL model, a unique antigen-specific interpretive framework, provides a mechanism for the initiation of allergy and autoimmunity in light of the 'Hygiene hypothesis'. To read click SPIRAL 1.
September 8, 2017
We are pleased to announce that a brief practical guide to the SPIRAL, a unique interpretive framework that represents the periodic table of cross-reactive Foxp3+ regulatory T cell (Treg) epitopes has been published in PeerJ Preprints. To download click SPIRAL 1.
July 10, 2017
We are pleased to announce that a draft paper introducing the science behind the SPIRAL framework has been published in PeerJ Preprints. To download click SPIRAL 1.